Interaction between Cannabinoid System and Toll-Like Receptors Controls Inflammation

External human exposure and management immune system in pathogenesis of irritable bowel syndrome

External exposed radiation may play an important role in pathogens of irritable bowel syndrome (IBS), although is thought to arise due to a combination of genetic and environmental factors. The result is dysregulated immune responses due to alteration in the gut microbiota population and the subsequent development of gut inflammation. It has recently been shown that the effect of ioni...

Endoplasmic reticulum stress regulates inflammation in adipocyte of obese rats via toll-like receptors 4 signaling

Objective(s): To explore whether endoplasmic reticulum (ER) stress regulates inflammation in adipose tissue of obese rats via TLR4 signaling. Materials and Methods: Sprague Dawley rats were randomly divided into four groups, and body weight, food intake, and free fatty acids (FFA) were measured. Real-time PCR and Western blot were used to determine mRNA or protein expression of TLR4, TRAF6, IKK...

Interaction between cannabinoid receptors and inhibition of L-type calcium channel on passive avoidance learning and memory in male rats

Introduction: There is currently a debate over the interaction between Ca2+ channels and cannabinoid system on learning and memory processing. In this study, we examined the effect of acute injection of cannabinoid agonist (Win- 55212-2) (Win) or antagonist (AM251), following chronic injection of verapamil, as a L-type Ca2+ channels blocker, on passive avoidance (PA) test in male Wistar rats...

P-225: Gene Variations of Toll-Like Receptor 3 in Endometriosis

Background: Endometriosis is a common gynecologic disorder that is characterized by the ectopic growth of endometrial tissue. Recently, endometriosis has been alternatively described as an immune, genetic and hormonal disease caused by exposure to environmental factors. Toll-like receptor 3 (TLR3) comprises a family of receptors through directly recognizing exogenous and endogenous ligands play...

Gene expression quantification of toll like receptors 2, 4 and co-molecules in human glioblastoma Cell Line (U87-MG): Toward a New In vitro Model of Inflammation